10 Celebrities With Real Genetic Mutations

The actress and humanitarian tested positive for a BRCA1 gene mutation, which significantly increases the risk of developing breast and ovarian cancer.

Angelina Jolie - BRCA1 Gene Mutation

Hanks carries the thalassemia trait, a genetic condition affecting the production of hemoglobin and causing mild anemia.

Tom Hanks - Thalassemia Trait

The Olympic swimmer has Marfan syndrome, a genetic disorder that affects connective tissues and can result in long limbs and a flexible body.

Michael Phelps - Marfan Syndrome

The actor and comedian reportedly has a rare genetic condition known as Atkinson's Syndrome, which causes him to have a unique appearance and speech patterns.

Rowan Atkinson - Atkinson's Syndrome

Garcia has syndactyly, a genetic condition where fingers or toes are fused together, usually in the form of webbing.

Andy Garcia - Syndactyly

Aykroyd has heterochromia, a condition where the irises of the eyes have different colors, giving his eyes a distinct and striking appearance.

Dan Aykroyd - Heterochromia

The stunt performer and TV personality was born with a congenital limb deficiency, which resulted in the partial amputation of one of his hands.

Steve-O - Congenital Limb Deficiency

Bosworth also has heterochromia, with one eye being blue and the other being hazel, contributing to her unique and captivating look.

Kate Bosworth - Heterochromia

Whitaker has ptosis, a condition where the upper eyelid droops, adding to his distinctive and expressive appearance.

Forest Whitaker - Ptosis

Walken has Dupuytren's contracture, a condition where the connective tissue in the hand thickens, causing the fingers to bend inward.

Christopher Walken - Dupuytren's Contracture

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